Wednesday 31 January 2018

Diabetes

The high blood sugar level may eventually damage the nerves especially in the feet. When the nerves are damaged the patient does not feel pain and will not know if he/she has an injury. The patient may continue walking without protecting the wound, the wound may aggravates and develop in foot ulcer.

High blood sugar levels may also damage blood vessels, resulting in poor blood supply to the area, less blood supply means less nutrients-oxygen for the tissue cells. So the ulcer becomes more infected , the infection grows rapidly and Gangrene develops.Now Diabetic foot Ulcer may converts in Diabetic foot Gangrene

Diabetic foot ulcer is a major complication of diabetes mellitus, and probably the major component of the diabetic foot. It occurs in 15% of all patients with diabetes and precedes 84% of all lower leg amputations. Major increase in mortality among diabetic patients, observed over the past 20 years is considered to be due to the development of macro and micro vascular complications, including failure of the wound healing process. Wound healing is an innate mechanism of action that works reliably most of the time. A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM) that forms the largest component of the dermal skin layer. Controlled and accurate rebuilding is essential to avoid under- or over-healing that may lead to various abnormalities. But in some cases, certain disorders or physiological insult disturbs the wound healing process. Diabetes mellitus is one such metabolic disorder that impedes the normal steps of the wound healing process. Many histopathological studies show a prolonged inflammatory phase in diabetic wounds, which causes a delay in the formation of mature granulation tissue and a parallel reduction in wound tensile strength.

0 comments:

Post a Comment

Related Posts Plugin for WordPress, Blogger...
Related Posts Plugin for WordPress, Blogger...
Submit Blog & RSS Feeds
blog search directory

Popular Posts